Reference of 23426-63-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 23426-63-3, name is Methyl 2-bromo-2-methylpropanoate, This compound has unique chemical properties. The synthetic route is as follows.
A 3 neck round bottom flask equipped with a mechanical stirrer, thermometer, condenser and nitrogen bubbler, was charged with malononitrile (251 g, 3.80 moles) and THF (2 liters). t-BuOK (1 M THF, 3.80 L, 3.80 moles) was then added. The mixture was stirred at 50C for 0.5 h. Methyl 2-bromoisobutyrate (688 g, 3.80 moles) was added and the reaction mixture was stirred overnight at 50C. The reaction was partitioned between aqueous 1 N HCI and EtOAc. The organic phase was washed with brine, dried over anhyd. magnesium sulfate, filtered, and concentrated to afford the title compound. H NMR (400 MHz, CD3CN): delta 4.35 (1 H, s) 3.73 (3H, s), 1.43 (6H, s).
The chemical industry reduces the impact on the environment during synthesis Methyl 2-bromo-2-methylpropanoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK SHARP & DOHME CORP.; GARFUNKLE, Joie; ORNOSKI, Olga; PARKER, Dann, L., Jr.; RAGHAVAN, Subharekha; XU, Libo; (88 pag.)WO2016/191334; (2016); A1;,
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