110661-91-1, name is tert-Butyl 4-bromobutanoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: tert-Butyl 4-bromobutanoate
Intermediate 6 (10.47 g, 11.73 mmol) was dissolved in acetonitrile (500 ml) and tert-butyl bromoacetate (10.0 g, 44.84 mmol) and DIPEA (9.08 mg, 70.38 mmol) were added. The reaction mixture was stirred at RT for 14 days and then filtered. Evaporation of the solvent gave crude product which was purified using a Combiflash companion (120 g cartridge) eluting with 0-10% MeOH in DCM. The solid product was triturated with Et2O to give a white solid. Yield: 8.79 g (72%) LC-MS (Method 2): Rt = 2.93 min, m/z = 1036 [M+H]+
The synthetic route of 110661-91-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARGENTA DISCOVERY LIMITED; WO2009/60206; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics