Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27798-60-3, name is Methyl 2-Methoxyphenylacetate, A new synthetic method of this compound is introduced below., HPLC of Formula: C10H12O3
General procedure: A solution of 2.5 M n-BuLi in hexane (1.2 equiv) was added dropwise to a solution of HMDS (1.2 equiv) in anhyd THF at -78 C under argon, and then, after stirring of the mixture for 10 min, a solution of alkyl 2-arylacetate (1 equiv) in THF was added in one portion. The mixture was stirred for 10 min, after which a solution of acyl chloride (1.15 equiv) in THF was added in one portion and the mixture was stirred for 15 min at -78 C and then overnight at r.t. The reaction mixture was quenched with sat. aq NH4Cl, extracted with EtOAc or Et2O, and the organic layer was washed with brine and dried over Na2SO4. The solvents were evaporated to give 3-substituted alkyl 2-aryl-3-oxopropanoate 5, which was used without further purification. NH2OH¡¤HCl (2-5 equiv) was added to a solution of 5 in MeOH and the mixture was refluxed for 24 h. The solvent was evaporated, the residue was treated with H2O, and the precipitate that formed was filtered, washed with H2O and a mixture of PE/EtOAc (10:1), and then dried in air to give pure 3-substituted 4-aryl-5-hydroxyisoxazole/4-arylisoxazol-5(4H)-one 6. The yields of 6 were calculated for the two steps, and is based on the starting alkyl 2-arylacetate.
The synthetic route of 27798-60-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bodunov, Vladimir A.; Galenko, Ekaterina E.; Galenko, Alexey V.; Novikov, Mikhail S.; Khlebnikov, Alexander F.; Synthesis; vol. 50; 14; (2018); p. 2784 – 2798;,
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