Adding a certain compound to certain chemical reactions, such as: 39149-80-9, name is tert-Butyl 2-bromopropanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39149-80-9, Product Details of 39149-80-9
Sodium hydride (60% dispersion in mineral oil) (1.02 g, 25.43 mmol) was added to a solution of methyl 2-(2-bromo-4-fluorophenyl)acetate (5.24 g, 21.19 mmol) and 1,3- dimethyl-3,4,5,6-tetrahyaYo-2(lH)-pyrimidinone (2.56 mL, 21.19 mmol) in anhydrous THF (50 mL). The reaction mixture was stirred for 15 min. before a solution of tert-butyl- 2-bromopropionate (5.32 g, 25.43 mmol) in anhydrous THF (5 mL) was added to it. The reaction mixture was stirred at room temperature overnight. The reaction mixture was heated to 60C for a further 24 h. After that time, the mixture was cooled to room temperature and poured onto water. The mixture was extracted with EtOAc and the combined organic layers were washed with brine, dried (Na2S04), filtered and concentrated in vacuo. The crude material was purified by column chromatography on silica, eluted with 10% EtOAc/hexane to afford the title compound. (0689) ?H NMR (400 MHz, CDCb) 8ppm 0.87 – 1.01 (m, 2 H), 1.19 (s, 4 H), 1.23 – 1.29 (m, 1 H), 1.46 (s, 5 H), 2.92 – 3.23 (m, 1 H), 3.55 – 3.72 (m, 3 H), 4.29 – 4.46 (m, 1 H), 6.94 – 7.07 (m, 1 H), 7.26 – 7.49 (m, 2 H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl 2-bromopropanoate, and friends who are interested can also refer to it.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; LIWICKI, Gemma; MACK, Stephen; STEPHENSON, Anne; TEALL, Martin; WHITE, Kathryn; (168 pag.)WO2018/47983; (2018); A1;,
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