Related Products of 7149-03-3, A common heterocyclic compound, 7149-03-3, name is Ethyl 4-amino-3-bromobenzoate, molecular formula is C9H10BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 11b (11.8 g, 48.34 mmol) was dissolved in concentrated hydrochloric acid (60.43 mL, 12N) at -10C, then a solution of sodium nitrite (4.00 g, 58.01 mmol) in water (300 mL) was added dropwise. The resulting reaction solution was reacted at 0C for 0.5 hour, and added at -10C in portions to another reaction vessel containing cuprous chloride (1.44 g, 14.50 mmol) and liquid sulfur dioxide (9.29 g, 145.03 mmol). . The resulting reaction solution was reacted at 0C for 0.5 hours. After extraction with ethyl acetate (100 mL¡Á3), the organic phase was washed with saturated brine (100 mL¡Á3), dried over anhydrous sodium sulfate, filtered, and concentrated to give compound 11c (14.00 g).
The synthetic route of 7149-03-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhengda Tianqing Pharmaceutical Group Co., Ltd.; Nanjing Mingde Drug Discovery Co., Ltd.; Yao Yuanshan; Chen Bin; Chen Yuan; Li Ao; Xu Ran; Huang Zhensheng; Tian Dongdong; Li Hongwei; Yang Chengshuai; Li Jian; Chen Shuhui; (26 pag.)CN107987072; (2018); A;,
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