Adding a certain compound to certain chemical reactions, such as: 84228-44-4, name is Methyl 4-amino-3-chlorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84228-44-4, Recommanded Product: 84228-44-4
To a solution of methyl 4-amino-3-chlorobenzoate (0.37g, 0.002 mol) and diisopropylethylamine (0.39g, 0.003 mole) in dioxane at ambient temperature was added in one portion 2-oxo-l ,2-dihydro-3-pyridinecarbonyl chloride (0.4g, 0.002 mol) [prepared as described in WO/201 1/088201 Al]. The mixture was heated at reflux for 24 h. after which it was cooled to ambient temperature and partitioned between EtOAc and water. The two phase material was filtered and the solid was washed with water, then EtOAc and air dried to obtain a 25% yield of the title compound as an off-white solid. MS: m z 305 (MIT) and m/z 307 (MH+). NMR (500 MHz, DMSO-d6): delta 3.848 (s, 3H), 6.604 (t, 1H), 7.878 (qd, 1H), 7.942 (dd, 1H), 8.015 (d, 1H), 8.504 (dd, 1H), 8.744 (d, 1H), 12.787 (br s, 1H), 12.893 (s, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-amino-3-chlorobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NORTH CAROLINA CENTRAL UNIVERSITY; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; SEXTON, Jonathan Z.; BRENMAN, Jay E.; WO2014/165816; (2014); A1;,
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