Related Products of 344-14-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 344-14-9, name is Dimethyl 2-fluoromalonate, This compound has unique chemical properties. The synthetic route is as follows.
Dimethyl 2-fluoromalonate (77.00g, 0.80mol, 2.0eq.) Was dissolved in 1L of tetrahydrofuran, cooled to -40 , 1M NaHMDS tetrahydrofuran solution (800mL, 0.80mol, 2.0eq. ), After stirring for 1h, add 400mL of a compound of formula (50g, 0.40mol, 1.0eq.) In tetrahydrofuran solution 400mL, return to room temperature after completion of the dropwise reaction for 2h, add 500mL of saturated ammonium chloride aqueous solution to separate, organic The phase was washed with saturated brine, dried, concentrated, column chromatography (petroleum ether / ethyl acetate), and concentrated to obtain 99.7 g of the compound of formula III, with a yield of 45.1%.
The chemical industry reduces the impact on the environment during synthesis Dimethyl 2-fluoromalonate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Nanjing Furunkaide Bio-pharmaceutical Co., Ltd.; Zhang Leiliang; Xu Feng; (16 pag.)CN110963955; (2020); A;,
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