Adding a certain compound to certain chemical reactions, such as: 1150566-27-0, name is Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1150566-27-0, category: esters-buliding-blocks
To a suspension of ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate (I-7) (128 mg, 0.565 mmol) in DMSO (2.5 mL) was added (3S)-3-(tert-butyldimethylsilyloxy)-2-(3-fluorophenyl)pyrrolidine (I-53) (167 mg, 0.565 mmol) and potassium floride (328 mg, 5.65 mmol). The mixture was heated at 120 C. overnight. The mixture was poured into water and extracted with EtOAc twice. The combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated. The crude product was purified by column chromatography on silica gel with EtOAc/hexanes gradient as eluant to yield ethyl 6-((3S)-2-(3-fluorophenyl)-3-hydroxypyrrolidin-1-yl)imidazo[1,2-b]pyridazine-3-carboxylate (I-54). MS m/z 371.1 (M+1)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; IRM LLC; US2012/65184; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics