Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4934-99-0, name is Methyl 3-hydroxycyclobutanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 4934-99-0
To a solution of methyl 3-hydroxycyclobutanecarboxylate (1.2 g, 9.0 mmol) in DMF (20 mL) was added sodium hydride (60%> wt in mineral oil) (1.8 g, 45 mmol) at RT. The mixture was stirred for 1 h and then 2, 5-difluoro-3-(tetrahydro-pyran-4-yl)-pyridine (1.8 g, 9.0 mmol) was added. The reaction mixture was heated to 60 C for 3 h and then quenched with saturated NH4C1. The solution was diluted with EtOAc and water and extracted with EtOAc (2xl0mL). The organic extracts were combined, washed with brine (lOmL), dried over MgS04, filtered, and concentrated to get a residue, which was purified by flash column chromatography on silica gel (5% to 30%> EtOAc in hexanes) to give the product (3.2 g) as yellow oil.
According to the analysis of related databases, 4934-99-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AMGEN INC.; ALLEN, Jennifer; FROHN, Michael; HARRINGTON, Paul; PICKRELL, Alexander; RZASA, Robert; SHAM, Kelvin; HU, Essa; WO2011/143366; (2011); A1;,
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