Adding a certain compound to certain chemical reactions, such as: 454-31-9, name is Ethyl 2,2-difluoroacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 454-31-9, Recommanded Product: 454-31-9
To a solution of 1-bromo-4-iodobenzene (28.3 g, 0.100 mol) in anhydrous THF (300 mL) at -78 was added n-BuLi (2.5 M, 44.0 mL, 0.110 mol) , and the resulting mixture was stirred for 30 min before ethyl 2, 2-difluoroacetate (13.6 g, 0.110 mol) was added dropwise. After the addition, the mixture was stirred at -78 for 1 h, then excess base was quenched with aqueous 1N HCl solution (80 mL) . The product mixture was warmed to ambient temperature and extracted with MTBE (400 mL ¡Á 3) . The combined organic layers were washed with brine, dried over anhydrous sodium sulfate and concentrated to afford the title compound. MS: m/z 236.2 (M + 1) .1H NMR (400 MHz, DMSO-d6) delta 7.96 (d, J 8.0 Hz, 2H) , 7.85 (d, J 8.0 Hz, 2H), 7.28 -7.02 (m, 1H) .
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2,2-difluoroacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; COOKE, Andrew J.; PITTS, Daniel; JOHNSON, Adam; BESHORE, Douglas C.; HURZY, Danielle; MITCHELL, Helen; FRALEY, Mark; MCCOMAS, Casey; SCHIRRIPA, Kathy; MERCER, Swati P.; NANDA, Kausik; MENG, Dongfang; WU, Jane; BABAOGLU, Kerim; LI, Chun Sing; MAO, Qinghua; QI, Zhiqi; (156 pag.)WO2016/54807; (2016); A1;,
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