Adding a certain compound to certain chemical reactions, such as: 431-47-0, name is Methyl 2,2,2-trifluoroacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 431-47-0, Application In Synthesis of Methyl 2,2,2-trifluoroacetate
N-benzyl p-toluenesulfonamide (100 mg, 0.38 mmol), DMF (4 mL), potassium t-butoxide (129 mg, 1.15 mmol, 3 eq.) was added to the reaction flask in turn, and stirred at room temperature for 5 minutes. After the potassium tert-butoxide was uniformly dispersed, methyl trifluoroacetate (0.15 mL, 1.52 mmol, 4 eq.) was slowly injected into the reaction flask, and after 10 hours of reaction, stirring was stopped. It was extracted twice with ethyl acetate and distilled water, and then washed with a saturated NaCI solution. The magnesium sulfate was removed by filtration, and the solvent was evaporated. Purification by column chromatography to give N-methyl-N-benzyl-p-toluenesulfonamide (104 mg, yield 100%)
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Reference:
Patent; Guangdong Petrochemical College; Xiao Duoduo; Zheng Xin; Zeng Jiechun; Huang Jiawei; Zhou Rujin; Guan Ying; Liang Jieling; (8 pag.)CN109369506; (2019); A;,
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