Reference of 1559-02-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1559-02-0 as follows.
In the 2L three-mouth reaction bottle,Add 255.3 g of diethyl 1,1-cyclopropanedicarboxylate,840mL EtOH,The ice water bath cools it to 0 C.Slowly add 137.32g KHCO3The temperature control is added below 30 C.Naturally rise to room temperature,Stir the reaction for 15 h,TLC monitors the reaction completely,Add 1L of water,Extracted with (PE: EA = 1:1) 300 mL ¡Á 2,Remove the organic phase,Concentrated HCl adjusts pH=2,Extracted with EA 370mL¡Á2,Take the organic phase,Desolvent1,1-cyclopropanedicarboxylic acid monoethyl ester 201.7 g,The yield was 93%.
According to the analysis of related databases, 1559-02-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Wuhan Institute of Technology; Huang Qimao; Feng Jinjin; Gao Hui; (13 pag.)CN105111155; (2018); B;,
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