Related Products of 4934-99-0, A common heterocyclic compound, 4934-99-0, name is Methyl 3-hydroxycyclobutanecarboxylate, molecular formula is C6H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under N2 atmosphere, a solution of methyl 3-hydroxycyclobutanecarboxylate (7 g, 53.8mmol) in DCM (200 mL) was cooled to -78 oc and DAST (35 mL, 265 mmol, 1.22 g/mL) wasadded. The mixture was stirred at -78 C for 1 h, and the reaction was allowed to warm tort andstirred overnight. The reaction mixture was quenched with H20 (50 mL) at 0 C, and extractedwith DCM (200 mL x 3). The combined organic layers were dried over anhydrous Na2S04, andthen concentrated in vacuo to give the title compound as brown oil (7 g, yield 98.5%). 1HNMR (400 MHz, CDCh) 8 (ppm): 3.70 (s, 3H), 3.58 (q, J= 7.2 Hz, 1H), 3.15-3.10 (m, 1H),2.85-2.76 (m, 1H), 2.54-2.41 (m, 3H);19F NMR (376 MHz, CDCh) 8 (ppm): -151.8.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; DAI, Weilong; XI, Ning; LI, Minxiong; ZHANG, Tao; LI, Xiaobo; HU, Haiyang; CHEN, Wuhong; WANG, Tingjin; LIU, Jun; (188 pag.)WO2017/48675; (2017); A1;,
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