Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 711-01-3, name is Methyl adamantane-1-carboxylate, A new synthetic method of this compound is introduced below., Safety of Methyl adamantane-1-carboxylate
In the 10mL single-mouth bottle,Nitrogen protection,97.1 mg (0.50 mmol) of compound 1k is added,2.5mL hexane,105.9 mg (2.25 mmol) deuterated ethanol (EtOD),129.3 mg (2.25 mmol) of sodium reagent (40 wt% dispersion in mineral oil,Particle size 5-10mum),Stir for 5 min at 0C.Rise to room temperatureThe reaction was quenched with 3.0 M aqueous hydrochloric acid.Add ether and saturated brine to extractThe organic phase is dry,Concentrate, column chromatography,79.9 mg of the target compound, 4 gYield 95%.
The synthetic route of 711-01-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; China Agricultural University; An Jie; Lei Peng; Han Minhui; Ma Xiaodong; Wu Yufei; A Dila¡¤adijiang; Ding Yuxuan; (15 pag.)CN107445798; (2017); A;,
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