Adding a certain compound to certain chemical reactions, such as: 927-68-4, name is 2-Bromoethyl acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 927-68-4, name: 2-Bromoethyl acetate
After dissolving ethyl imidazole-2-carboxylate (200 mg, 1.43 mmol) in 5 ml of N,N-dimethylformamide and adding cesium carbonate (931 mg, 2.85 mmol) for 0.5 h,Add 2-bromoethyl acetate (385mg, 2.14mmol), warm to 80 for 2h, complete the reaction by TLC, stop the reaction, cool to room temperature, dilute with water,Extract with ethyl acetate (3¡Á20 ml), combine the organic layers, wash with saturated brine, dry over anhydrous sodium sulfate, filter and concentrate to obtain crude product.Purified by column chromatography (PE: EA=3: 1) to give a pale yellow liquid, ie compound1-(2-acetoxyethyl)-1H-imidazole-2-carboxylic acid ethyl ester 26b (300 mg, yield 92.8%).
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Reference:
Patent; Sichuan University; Li Guobo; Wang Zhenling; (36 pag.)CN111253317; (2020); A;,
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