46193-76-4, name is Ethyl 4H-thieno[3,2-b]pyrrole-5-carboxylate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 46193-76-4
To a solution of 4H-thiophene [3,2-b] pyrrole-5-carboxylic acid ethyl ester (4.24 g, 21.7 mmol) in DMF (20 mL) at room temperature was added K2CO3 (7.82 g, 56.6 mmol),Then iodomethane (2.52 g, 17.8 mmol) was added dropwise.The mixture was stirred at room temperature for 2 h.The reaction was quenched with water and extracted with EtOAc (3 ¡Á).The combined organic phases were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure.The residue was purified by silica gel chromatography,Elution with 0-10% EtOAc in hexanes gave the title compound (3.96 g, 18.9 mmol, 87% yield).
The synthetic route of 46193-76-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Beijing Jiakesitu Drug Discovery Co., Ltd.; Beijing Jiakesi Drug Discovery Co., Ltd.; Fang Haiquan; Li Haijun; Yang Guiqun; Wang Yanping; Wu Lingjun; Li Qinglong; Du Yuelei; Zhang Lei; Hu Shaojing; (65 pag.)CN110407854; (2019); A;,
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