Electric Literature of 33842-16-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33842-16-9 name is Methyl benzo[d][1,3]dioxole-4-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Method C; BenzoH ,31dioxole-4-carboxylic acidhydrazide (Intermediate compound); A mixture of 1 ,3-benzimidazole-4-carboxylic acid (3.0 g, 17,5 mmol), sulfuric acid (0.17 g, 1.75 mmol) and methanol (40 ml) was stirred at reflux for 15 h. The mixture of the intermediate benzo[1 ,3]dioxole-4-carboxylic acid methyl ester was allowed to reach room-temperature. Hydrazine monohydrate (8.5 g, 175 mmol) was added and the mixture was stirred at reflux for 15 h. The mixture was evaporated, water was added and the crystalline product was isolated by filtration. Yield 2.15 g (68%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl benzo[d][1,3]dioxole-4-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; NeuroSearch A/S; PETERS, Dan; TIMMERMANN, Daniel, B.; NIELSEN, Elsebet, ?stergaard; DYHRING, Tino; CHRISTENSEN, Jeppe, Kejser; WO2010/86278; (2010); A1;,
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