These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-(4-(benzyloxy)phenyl)propanoate, its application will become more common.
Related Products of 24807-40-7,Some common heterocyclic compound, 24807-40-7, name is Methyl 3-(4-(benzyloxy)phenyl)propanoate, molecular formula is C17H18O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Methyl 2-((4-((phenylmethyl)oxy)phenyl)methyl)butanoate(32.1).; To a solution of lithium diisopropylamide (6.5 mL, 2.0 M in heptane/THF/ethylbenzene) in THF (25.0 mL) and l,3-dimethyl-3,4,5,6- tetrahydro-2(lH)-pyrimidinone (5.0 mL) was added methyl 3-(4- (benzyloxy)phenyl)propanoate 23.1 (3.00 g, 1 1 mmol) in THF (1OmL) and 1,3- dimethyl-3,4,5,6-tetrahydro-2(lH)-pyrimidinone (2.5 mL) at -780C. The resulting mixture was stirred at -780C for 30 minutes and then iodoethane (1.0 mL, 13 mmol) in THF (5.0 mL) was added. The reaction mixture was stirred at the same temperature for 20 minutes. The reaction was then stirred at room temperature for 16 hours. The reaction was quenched with water (30.0 mL), and the mixture was concentrated in vacuo. The residue was disolved in EtOAc (100 mL), washed with brine (2×25 mL), and dried with Na2SO4. The residue was purified by silica gel column (eluent with hexane/EtOAc; 85/15) to give the title compound 32.1. MS ESI (pos.) m/e: 299.0 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-(4-(benzyloxy)phenyl)propanoate, its application will become more common.
Reference:
Patent; AMGEN INC.; WO2008/130514; (2008); A1;,
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