Adding a certain compound to certain chemical reactions, such as: 106614-28-2, name is Methyl 2,4-difluorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 106614-28-2, SDS of cas: 106614-28-2
Intermediate 28: Methyl 2-fluoro-4-(piperazin-1-yl)-benzoate Dimethyl sulfoxide (1.0 ml) was added to 544 mg of piperazine to prepare a suspension, and 368 mg of methyl 2,4-difluorobenzoate was added to the suspension. The mixture was stirred at 80 C. for 1 hr and was then cooled to room temperature. The reaction solution was concentrated under the reduced pressure. The residue was purified by column chromatography on silica gel (development system: methylene chloride-methanol-concentrated aqueous ammonia=900:100:1) to prepare 274 mg of the title compound. Physicochemical Properties of Intermediate 28
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Reference:
Patent; Meiji Seika Kaisha, Ltd.; US6451800; (2002); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics