Reference of 1245643-11-1, A common heterocyclic compound, 1245643-11-1, name is Methyl 3,4-diamino-5-bromobenzoate, molecular formula is C8H9BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
TsOH?H20 (0.388 g, 2.04 mmol) was added to a mixture of triethylorthoformate (6.8 mL, 40.8 mmol) and methyl 3,4-diamino-5-bromobenzoate (5.0 g, 20.4 mmol) in THF (150 mL). The mixture was stirred at 20C for 5 hours. After cooling to room temperature, the mixturewas concentrated under reduced pressure. EtOAc (20 mL) was added to the crude residue and the mixture was filtered. The filter cake was collected to give methyl 7-bromo- 1H- benzo[d]imidazole-5-carboxylate (4.0 g, 77% Yield) as a pink solid. ?H NMR (400 MHz, DMSO) (5 13.10 (br s, 1H), 8.51 (s, 1H), 8.17 (s, 1H), 7.96 (s, 1H), 3.87 (s, 2H).
The synthetic route of 1245643-11-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; STIVALA, Craig; HEFFRON, Timothy; (243 pag.)WO2019/57946; (2019); A1;,
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