Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 85953-29-3, name is Methyl 2-chloro-4-fluorobenzoate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 2-chloro-4-fluorobenzoate
A mixture of tert-butyl 4,4′-bipiperidine-l -carboxylate (1-2) (268 mg, 1 mmol, 1.0 eq), methyl 2- chloro-4-fluorobenzoate (5-1) (226 mg, 1.2 mmol, 1.2 eq) and K2CO3 (414 mg, 3 mmol, 3 eq) in NMP (5 ml) was stirred at 120 C for 3 h. After cooling to room temperature, the mixture was diluted with EtOAc (80 niL), washed with water (20 mL x3), brine (10 mL), dried over sodium sulfate and purified by column chromatography (PE:EA =5: 1-3: 1 ) to give tert-butyl l’-(3- chloro-4-(methoxycarbonyl)phenyl)-4,4′-bipiperidine-l-carboxylate (5-2). LRMS m/z (M+Na) 459.2 found, 459.2 required
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK SHARP & DOHME CORP.; STACHEL, Shawn, J.; BENNETT, David Jonathan; BRNARDIC, Edward, J.; LIVERTON, Nigel, J.; MANLEY, Peter, J.; MENG, Zhaoyang; NANDA, Kausik, K.; RUDD, Michael, T.; WAI, Jenny; (137 pag.)WO2017/83219; (2017); A1;,
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