Electric Literature of 541-16-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 541-16-2 as follows.
To a suspension of benzyltriethylammonium chloride (21.0 g, 92.2 mmol) in a 50% aqueous NAOH solution (92.4 g in 185 mL H20) was added 1,2- dibromobutane (30.0 g, 138.9 mmol) and DI-TERT-BUTYLMALONATE (20.0 g, 92.5 mmol). The reaction mixture was vigorously stirred 18 h at rt, a mixture of ice and water was then added. The crude product was extracted with CH2CI2 (3x) and sequentially washed with water (3x), brine and the organic extracts combined. The organic layer was dried (MgS04), filtered and concentrated in vacuo. The resulting residue was flash chromatographed (100 G SI02, 3% ET20 in hexane) to afford the titled product (18.3 g, 67.8 mmol, 73% yield) which was used directly in the next reaction.
According to the analysis of related databases, 541-16-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/99316; (2003); A1;,
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