Synthetic Route of 178312-47-5,Some common heterocyclic compound, 178312-47-5, name is Ethyl 4,4-difluorocyclohexanecarboxylate, molecular formula is C9H14F2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution ofbutyllithium(2.000 mL, 2.80 mmol) was added to a cold (-78 C.) solution ofdiisopropylamine(0.396 mL, 2.80 mmol) inTHF(5 mL) under N2and the mixture was stirred at -78 C. for 1 h. A solution ofethyl 4,4-difluorocyclohexanecarboxylate(384 mg, 2 mmol) in THF (2 mL) was added at -78 C. and the mixture was stirred for 1 h and then gradually warmed to -20 C. over 2 h and then re-cooled to -78 C. Neat((chloromethoxy)methyl)benzene(0.226 mL, 2.200 mmol) was added and the mixture was allowed to warm to rt over 2 h. The reaction was quenched with satd. NH4Cl and extracted with EtOAc and washed with water, brine, dried (Na2SO4). Evaporation of the solvent afforded a lightyellowoil which was purified by silica gel FCC (1:1 DCM-hexanes) to afford1-((benzyloxy)methyl)-4,4-difluorocyclohexanecarboxylateas acolorlessoil.
The synthetic route of 178312-47-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hewawasam, Piyasena; Lopez, Omar D.; Tu, Yong; Wang, Alan Xiangdong; Xu, Ningning; Kadow, John F.; Meanwell, Nicholas A.; Gupta, Samayamuthula Venkata Satya Arun Kumar; Kumar, Indasi J. Gopi; Ponugupati, Suresh Kumar; Belema, Makonen; US2015/23913; (2015); A1;,
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