Simple exploration of 99548-54-6

The synthetic route of 99548-54-6 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 99548-54-6, name is Methyl 3-bromo-2-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 99548-54-6

A mixture of 3-Bromo-2-methyl benzoic acid methyl ester (2.4 g, 10.29 mmol), NBS (1.83 g, 10.29 [MMOL)] and AIBN (4 mg) in [CHLOROBENZENE] (40 mi) was heated to [80C] under nitrogen for 18 hours. The mixture was cooled in an ice-bath, filtered and the solvent removed by evaporation under reduced pressure. The orange residue was purified by flash chromatography on silica gel eluting with a solvent gradient of heptane: ethyl acetate (40: 1) to give the title compound (2.74 g, 86 %) as a colourless oil. [1H-NMR] (400 MHz, [CDCI3)] : [ES] = 3.88 (s, 3H), 5.06 (s, 2H), 7.22 (dd, 1H), 7.68 (d, [1H),] 7. 89 (d, [1 H).] Microanalysis : Found: C, 35.21 ; H, 2.67 ; N, 0.00. [C9H8BR202] requires C, 35.10 ; H, 2.62 ; N, 0.00%.

The synthetic route of 99548-54-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/14357; (2004); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics