Reference of 927-68-4, These common heterocyclic compound, 927-68-4, name is 2-Bromoethyl acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Dissolve ethyl imidazole-2-carboxylate (200 mg, 1.43 mmol) in 5 ml of N,N-dimethylformamide, add cesium carbonate (931 mg, 2.85 mmol) and activate for 0.5 h, then add2-bromoethyl acetate(385mg, 2.14mmol), warmed to 80C for 2h, complete reaction by TLC, stop reaction, cooled to room temperature, diluted with water, extracted with ethyl acetate (3¡Á20ml), combined organic layers, washed with saturated brine, anhydrous Dry over sodium sulfate, filter, and concentrate to obtain crude product. Purified by column chromatography (PE:EA=3:1) to give a pale yellow liquid, namely compound 1-(2-acetoxyethyl)-1H-imidazole-2-carboxylic acid ethyl ester 26b (300mg, yield 92.8 %).
The synthetic route of 927-68-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sichuan University; Li Guobo; Wang Zhenling; (40 pag.)CN111187218; (2020); A;,
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