Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24812-90-6, name is Methyl 3-amino-4-methoxybenzoate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 24812-90-6
Anhydrous p-toluene sulfonic acid (41.99 g, 220.8 mmol) was melted at 120 C and 3-amino-4-methoxy benzoic acid methyl ester (20 g, 110.38 mmol) obtained in step 1 and benzonitrile (22.77 g, 220.8 mmol) were added thereto and stirred at 180 C for 5 hours. The resulting solution was cooled to room temperature and the reaction was stopped by adding NaHCO3 thereto. The resulting mixture was extracted with ethyl acetate, the extract was dried over MgS04 and concentrated under a reduced pressure. The concentrate was dissolved in 50 % methanol and 5 % NaOCl (56 ml, 37.65 mmol) was added dropwise thereto. After 5 min, the resulting mixture was extracted with ethyl acetate, the extract was dried over MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by silica gel column chlomatography (eluent-MeOH/CDCl3=5:95, Merck, Silicagel 60) to obtain the title compound (31 g, 25.10 mmol) in a yield of 88 %. 1H NMR (CDCl3): delta 7.78 (1H, d), 7.48 (1H, s), 7.37-7.24 (5H, m), 6.95 (1H, d), 3.78 (6H, s) MW: 318
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 24812-90-6.
Reference:
Patent; CRYSTALGENOMICS, INC.; YUYU INC.; WO2004/65370; (2004); A1;,
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