Reference of 369-26-6,Some common heterocyclic compound, 369-26-6, name is Methyl 3-amino-4-fluorobenzoate, molecular formula is C8H8FNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Methyl 3-amino-4-fluorobenzoate (275mg) and DMAP (100mg) were dissolved in pyridine (lOml). Then cyclopropanesulfonyl chloride (330mg) was added into the solution. The reaction mixture was heated to 110¡ãC and stirred for 12 hours until the reaction is complete. The solvent was stripped off, the solid was dissolved in CH2C12 (50m1) followed by iN HC1 solution (50m1). The bottom aqueous layer was split off and the organic layer was washed with water and dried by anhydrous Na2SO4. The CH2C12 was stripped off and 270mg of methyl 3 -(cyclopropanesulfonamido)-4-fluorobenzoate was used for the next step directly.
The synthetic route of 369-26-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHILADELPHIA HEALTH & EDUCATION CORPORATION, D/B/A DREXEL; INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH; ENANTIGEN THERAPEUTICS, INC.; BAUGH, Simon David Peter; YE, Hong; XU, Xiaodong; GUO, Ju-tao; XIAO, Tong; DU, Yanming; BLOCK, Timothy; WO2014/106019; (2014); A2;,
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