90030-48-1, name is Sodium 3-methoxy-3-oxopropane-1-sulfinate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: Sodium 3-methoxy-3-oxopropane-1-sulfinate
ADMSO (0.5 mL) solution of Example 318 (20 mg, 39 tmol), sodium 3-methoxy-3-oxopropane-1-sulfinate (20 mg, 116 tmol) and copper(I) iodide (22 mg, 116.imol) was heated in a sealed safety vial at 120 C for 4.5 h. The resulting mixture wasdiluted with MeOH (1 mL) and filtered. The filtrate was purified via preparative LC/MS(Condition A: Gradient: 20-60% B over 20 minutes, then a 5-minute hold at 100% B) to give (R)-methyl 3 -((3 -(1 -((3 -chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5 -yl)quinolin4-yl)amino)ethyl)-4-fluorophenyl)sulfonyl)propanoate (3 mg, 13% yield). LC/MS (M+H): 587; LC retention time: 1.87 mm (Method A). ?H NMR (500 MFIz, DMSO-d6) oe 9.26 (s, 2H), 8.75 (s, 1H), 8.49 (s, 1H), 8.18-8.11 (m, 2H), 8.00 (d,J=8.8 Hz, 1H), 7.80(br. s., 1H), 7.44 (t, J=9.3 Hz, 1H), 6.93 (d, J=8.5 Hz, 1H), 5.86-5.78 (m, 1H), 2.42-2.32 (m, 4H), 1.71 (d, J=6.7 Hz, 3H), 1.56 (s, 6H).
The synthetic route of 90030-48-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; XIAO, Hai-Yun; DHAR, T. G. Murali; LI, Ning; DUAN, Jingwu; JIANG, Bin; LU, Zhonghui; NGU, Khehyong; PITTS, William J.; TINO, Joseph; (402 pag.)WO2017/23905; (2017); A1;,
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