Related Products of 20372-66-1, A common heterocyclic compound, 20372-66-1, name is Methyl 2,4,5-trifluorobenzoate, molecular formula is C8H5F3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Methyl 2,4,5-trifluorobenzoate (DSL Chemicals; 950.61 mg; 5 mmol; 1 eq.), sodium cyanide (306.30 mg; 6.25 mmol; 1.25 eq.) and tetrabutylammonium bromide (2 014.82 mg; 6.25 mmol; 1.25 eq.) were dissolved in DMF (10 mL) . The resulting mixture was heated at 6O0C overnight. As the reaction was not complete, sodium cyanide (306.30 mg; 6.25 mmol; 1.25 eq.) was added and the mixture was stirred at 6O0C for additiona 24 h. The resulting dark pink solution was diluted with EtOAc and washed with brine several times. It was dried over MgSO4, filtrated and evaporated, resulting into a sticky dark red oil, which was purified by flash chromatography (Sitheta2 100 g, EtOAc / c-hex 1 :9 until 1 :1 ), affording the title product. 1H NMR (DMSO-d6, 300 MHz) delta 7.77 (dd, J = 5.45, 8.41 Hz, 1 H), 7.42 (dd, J = 4.99, 8.88 Hz, 1 H), 3.96 (s, 3H). LC/MS (Method A): 463.2 (M-H)”; 465.2 (M+H)+. HPLC (Method A) Rt 3.63 min (Purity: 99.9%).
The synthetic route of 20372-66-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SERONO S.A.; WO2009/43889; (2009); A2;,
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