Synthetic Route of 3469-00-9,Some common heterocyclic compound, 3469-00-9, name is Methyl Diphenylacetate, molecular formula is C15H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of diisopropylamine (0.17 mL, 1.19 mmol) in THF (1 mL) was added n-BuLi (2.5 M in hexane, 0.4 mL, 0.994 mmol) at -78 C. The reaction mixture was stirred at this temperature for 30 min, followed by stirring at -5 C for 30 min. Then, the reaction mixture was cooled to -78 C and diphenyl methylacetate (S6) (0.15 g, 0.66 mmol) in THF (2 mL) was added. After stirring at -78 C for 15 min, (E)-4,6-iodoheptadiene (S11) (0.16 g, 0.72 mmol) was added. The resulting solution was stirred at rt overnight. The reaction mixture was quenched with satd aq NH4Cl (10 mL) and extracted with EtOAc (2 x 50 mL). The extract was washed with water and brine, dried (MgSO4), filtered, and concentrated by rotary evaporation. Column chromatography of the residue (20:1 hexane/EtOAc) gave S12 (120 mg, 63%) as colorless oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl Diphenylacetate, its application will become more common.
Reference:
Article; Chandrasekhar; Ryu, Jae-Sang; Tetrahedron; vol. 68; 24; (2012); p. 4805 – 4812;,
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