In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 72338-48-8 as follows. category: esters-buliding-blocks
2.98 g of amantadine was dissolved in 15 mL of DMF, and 5.5 g of ethyl bromododecanoate and 4.9 g of K2CO3 were added.Reaction at 60 C for 16 hours;Then diluted with 100 mL of water and extracted with ethyl acetate (3¡Á50 mL);After the organic phase is combined, it is dried with sodium, and then the solid is filtered off.The filtrate is concentrated in vacuo and purified to give a yellow oil, 12-(adamantyl)aminododecanoate;
According to the analysis of related databases, 72338-48-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; China Agricultural University; Wang Zhanhui; Jiang Haiyang; Wen Kai; Shen Jianzhong; Zhang Xiya; Chen Chaochao; Duan Changfei; Yu Wenbo; Yu Xuezhi; (17 pag.)CN110105232; (2019); A;,
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