Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1236357-65-5, name is Methyl 1-(4-bromophenyl)cyclobutanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C12H13BrO2
To a 25 mL round-bottom t1ask purged with and maintained under an inertatmosphere of nitrogen was added (1 S,4S,5R)-.5-[ [ 5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2- oxazol-4-yl]methoxy ]-2-az.abicyclo[ 2.2.l]heptane hydroiodide salt l2dd (200 mg, 0.3943rnmol, 1.00 equiv.), Tol (lO mL), methyll-(4-bromophenyl)cyclobui:me-1-carboxylate 150b(212 mg, 0.79 mmol, 2.0 equiv.), Ru-Phos-Precatalyst (89 mg, 0.10 mmol, 0.25 equiv.),RuPhos (89 mg), and Cs2C01 (516 mg, 1.58 mmol, 4.00 equiv.). The resulting mixture was5 stirred at ll 0 C overnight and concentrated under vacuum. The residue vvas puriiled bysilica gel column chromatography eluting with ethyl acetate/petroleum ether (l/5) to affordmethyl 1-[4-[ (l S,4S,5R)-5-[ [ 5-cyclopropyl-3-(2,6-dichlorophenyl)- L2-oxazol-4-y l]methoxy ]-2-azabicydo[2.2.1]heptan-2-yl]pheny l]cyclobutane-1-carboxy late 150c (140rng, 63~”0) as a light yellow oil.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1236357-65-5.
Reference:
Patent; ARDELYX, INC.; CHAO, Jianhua; JAIN, Rakesh; HU, Lily; LEWIS, Jason Gustaf; BARIBAULT, Helene; CALDWELL, Jeremy; (582 pag.)WO2018/39386; (2018); A1;,
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