Synthetic Route of 685892-23-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 685892-23-3 as follows.
Step 1. Preparation of methyl 2-chloro-6-cyclobutylbenzoate (i-llb).A mixture of methyl 2-bromo-6-chlorobenzoate (i-ha) (750 mg, 3 mmol), (PPh3)4Pd (345 mg, 0.3 mmol) and cyclobutylzinc bromide (12 ml in THF, 6 mmol) were mixed under N2 protection. The mixture was stirred at 70C for 12 h under N2. The mixture was extracted with EtOAc and water. The organic phase was washed with brine, dried over Na2SO4, filtered, concentrated, and purified with chromatography (PE: EtOAc = 50:1) to give 350 mg (61% inLCMS, contained some PPh3) of the title compound. LCMS (ESI) calc?d for C12H13C102 [M+H]: 225, found: 225.
According to the analysis of related databases, 685892-23-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BARR, Kenneth Jay; MACLEAN, John; ZHANG, Hongjun; BERESIS, Richard Thomas; WO2014/28600; (2014); A2;,
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