As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 115118-68-8 name is Diisopropyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 115118-68-8
3-Oxo-cyclobutanecarboxylic acid; [1244] 3,3-Dimethoxy-cyclobutane-1,1-dicarboxylic acid diisopropyl ester (0.1 mmol, 30 g) was refluxed in 20% HCI aqueous solution for 60 h. Part of the HCI aqueous solution was evaporated under high vacuum and light brown color oil remained. The oil was dissolved by EtOAc and washed by brine. The organic layer was dried by NaS04, filtered, and evaporated under vacuum. The title compound was obtained as an off-white solid after recrystallization from chloroform.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diisopropyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate, and friends who are interested can also refer to it.
Reference:
Patent; OSI PHARMACEUTICALS, INC.; WO2005/97800; (2005); A1;,
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