Some common heterocyclic compound, 89-91-8, name is Methyl 2,2-dimethoxyacetate, molecular formula is C5H10O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 89-91-8
To a solution of methyl 2,2-dimethoxyacetate (8.7 g, 64.9 mmol, 7.98 mL, 1 eq) in dioxane (50 mL) and H20 (50 mL) was added LiOH H20 (3.27 g, 77.8 mmol, 1.2 eq) at 0 C . After addition, the mixture was stirred at this temperature for 1 h, and then the resulting mixture was stirred at 20C for 10 h. TLC indicated that one new spot formed. The reaction mixture was diluted with NaOH aqueous solution (1 M, 80 mL), and extracted with petroleum ether (80 mL x 3). The combined aqueous layers were acidified with HC1 (6 M) aqueous solution to pH=l, and then extracted with ethyl acetate (80 mL for 3 times). The combined organic layers were dried over Na2S04, filtered and concentrated under reduced pressure to give 3.54 g of a colorless oil, which was used directly in the next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 89-91-8, its application will become more common.
Reference:
Patent; SIGILON THERAPEUTICS, INC.; VEISEH, Omid; HEIDEBRECHT, Richard; WOTTON, Paul, Kevin; OBERLI, Matthias; MILLER, Robert, James; (498 pag.)WO2018/67615; (2018); A1;,
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