5616-81-9, The chemical industry reduces the impact on the environment during synthesis 5616-81-9, name is tert-Butyl 2-(methylamino)acetate, I believe this compound will play a more active role in future production and life.
To a solution of methyl-4-formyl benzoate (2.0 g, 12.2 mmol) and sarcosine /er/-butyl ester (2.7 g, 14.6 mmol) in 1 ,2-dichloroethane (60 mL) was added 10 drops of glacial acetic acid followed by sodium triacetoxy borohydride (5.6 g, 26.8 mmol). The reaction mixture was heated to 60C and stirred at this temperature for 20 hours. The solution was poured into aqueous saturated NaHCO3 and extracted twice with EtOAc. The combined organic phases were dried (MgSO4), filtered and concentrated in vacuo to afford 1.32 g of the desired product that was used without further purification: 1H NMR (400 MHz, cfe-DMSO) delta 7.91 (d, J= 8.0 Hz, 2H), 7.44 (d, J= 8.0 Hz, 2H), 3.83 (s, 3H), 3.69 (s, 2H), 3.18 (s, 2H), 2.23 (s, 3H), 1.42 (s, 9H); ESI+ MS: m/z (rel intensity) 294 (40, M+H).
The chemical industry reduces the impact on the environment during synthesis tert-Butyl 2-(methylamino)acetate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; METASTATIX, INC.; WO2008/109154; (2008); A1;,
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