28868-76-0, The chemical industry reduces the impact on the environment during synthesis 28868-76-0, name is Dimethyl 2-chloromalonate, I believe this compound will play a more active role in future production and life.
(1) In a 1 L reaction flask equipped with mechanical stirring, temperature display and distillation column, 430 ml of anhydrous dioxane was added.166.6 g of dimethyl chloromalonate and 10 g of dried potassium iodide;(2) 87.5 g of anhydrous potassium fluoride was activated by microwave drying, and added to the above reaction bottle;(3) heating to 100 C under reflux, and reacting for 1 hour;(4) collecting a fraction of 74-78 C through a distillation column;(5) The distillation temperature is up to 78 C to stop heating, to obtain crude dimethyl 2-fluoromalonate;(6) A total of 160g of crude product was collected, and the content of dimethyl 2-fluoromalonate was 91.6%, which was equivalent to 146.6 g of pure product;(7) Refining obtained 136 g of dimethyl 2-fluoromalonate, the content was 99.5%, and the yield was 90.2%.
The chemical industry reduces the impact on the environment during synthesis Dimethyl 2-chloromalonate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Sinopharm Group Chemical Reagent Co., Ltd.; Guo Jianguo; Gu Xiaoyan; Wu Xiaolan; Huang Hao; (4 pag.)CN109824512; (2019); A;,
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