A common heterocyclic compound, 2318-25-4, name is Ethyl 3-ethoxy-3-iminopropionate hydrochloride, molecular formula is C7H14ClNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 2318-25-4.
EXAMPLE 3F; Preparation of 5-ethoxythieno[3.2-b]pyridin-7-ol (3F3); Step A; To available thiophen-3-ylamine 3F1 (0.50 g, 5.04 mmol) was added imidate 3A2(1.08 g, 5.5 mmol) in ethanol (10 mL) under a N2 atmosphere. The mixture was stirred at RT. for 3 h at which point the reaction was concentrated. To the residue was added ether, and the suspension filtered and washed with ether to afford adduct 3F2(1.0g, 82percent). This material was sufficiently clean to be used in the subsequent step. MS: 242.1 (MH)+.
The synthetic route of Ethyl 3-ethoxy-3-iminopropionate hydrochloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GmbH & CO KG; WO2007/9227; (2007); A1;,
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