Adding a certain compound to certain chemical reactions, such as: 23877-12-5, name is tert-Butyl 2-bromo-2-methylpropanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23877-12-5, 23877-12-5
4-Hydroxybenzaldehyde (1) (5 g, 40.9 mmol) commercially available from Sigma-Aldrich was dissolved in N, N-dimethylformamide (50 mL) and potassium carbonate ), Magnesium sulfate (1.0 eq) and Tert-Butyl-a-bromoisobutyrate (5.0 eq) (R = -CH 3) were added in this order, and the mixture was stirred at 100 C for 22 hours. The reaction mixture was diluted with water and then extracted with ethyl acetate. The organic solvent layer was dried by adding anhydrous sodium sulfate, filtered, distilled, and purified by flash column chromatography to obtain the compound 2a (R = -CH3).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 2-bromo-2-methylpropanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Seoul National University R&DB Foundation; PARK, SEUNG-BUM; KOH, MIN-SEOB; KOO, JA-YOUNG; (32 pag.)KR101727634; (2017); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics