178312-47-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 178312-47-5, name is Ethyl 4,4-difluorocyclohexanecarboxylate, A new synthetic method of this compound is introduced below.
.4.4-Difluorocyclohexanecarbaldehvde; )-Propylmagnesium chloride (20 mL of a 2.0 M solution in THF, 40 mmol) was added dropwise to a oled (-150C) suspension of ethyl-4,4-difluorocyclohexanecarboxylate (3.0 g, 15.6 mmol) and N1O- nethylhydroxylamine hydrochloride (2.28 g, 23.4 mmol) in THF (30 mL). The reaction mixture was rred for 15 min then quenched with satd. NuH4Cl(aq). The product was extracted into ethyl acetate 2). The combined organic extracts were washed with brine, dried (MgSO4) and concentrated to give i-difluoro-iV-methoxy-N-methylcyclohexanecarboxamide as a clear oil (3.01 g, 93% yield). ? a solution of the aforementioned Wei?reb amide (3.0 g, 14.5 mmol) in diethyl ether (30 mL) at -780C is added, dropwise, diisobutylaluminium hydride (16 mL of a 1.0 M solution in toluene).On mpletion of addition, the mixture was stirred for a further 15 min before being poured into a stirred xture of diethyl ether (50 mL), hexanes (50 mL) and IN HCl(aq) (100 mL). The mixture was stirred r 5 rnins and then the layers were separated and the organic phase dried (MgSO4) and concentrated to /e 4)4-difluorocyclohexanecarboxaldehyde.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2006/134341; (2006); A1;,
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