4224-69-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4224-69-5 as follows.
General procedure: To a solution of 2a (0.30 g, 0.89 mmol) in a mixture of THF: H2O (20 mL, 2:1, v/v) were added allyl bromide (0.161 mL, 1.33 mmol) and indium powder (0.153 g, 1.33 mmol) and the reaction was continued for 3 h. On completion as monitored by TLC, the excess solvent was removed from the reaction to obtain a residue which was extracted with EtOAc (40 mL) and water (30 mL). The water layer was separated and further extracted with EtOAc (2 x 20 mL) and the organic layers were pooled, dried over anhyd. Na2SO4, and evaporated in vacuum to afford 3d (0.318 g, 93%) which was used further without purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4224-69-5, and friends who are interested can also refer to it.
Reference:
Article; Yadav, Veena D.; Srivastava, Kumkum; Tripathi, Renu; Batra, Sanjay; Tetrahedron; vol. 73; 38; (2017); p. 5680 – 5689;,
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