Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18448-47-0, name is Methyl cyclohex-1-enecarboxylate, A new synthetic method of this compound is introduced below., 18448-47-0
(4) Take 3.9g of 0.8g potassium carbonate (K2CO3),0.6g palladium on carbon (Pd (OH) 2 / C) and23mL tert-butyl hydroperoxide (TBHP),0 C was sequentially added to 80 mL of dichloromethane (DCM),The temperature was naturally raised to room temperature until the reaction was completed, and the allyl site was oxidized to form a carbonyl group.The reaction solution was then extracted with DCM, and the extract was separated by silica gel column chromatography.It is obtained that when R = H,4.1 g of product were obtained; when R = CH3,4.15 g of product was obtained.The reaction yield was 85%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shenzhen Elderly Medical Institute; Wu Zhengzhi; Tao Cheng; Liu Jieren; Li Limin; (6 pag.)CN110229064; (2019); A;,
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