Adding some certain compound to certain chemical reactions, such as: 18013-97-3, name is Diethyl 2,5-dibromoterephthalate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18013-97-3. 18013-97-3
To the crude was added anhydrous Lambda/,/V-dimethylformamide (100 cm3), 2,5-dibromo-terephthalic acid diethyl ester (1 1 .0 g, 29 mmol) and bis(triphenylphosphine)palladium(ll) dichloride (612 mg, 0.87 mmol) and the mixture heated at 100 C for 2 hours. The mixture allowed to cool to 23 C, concentrated in vacuo and passed through a plug of silica (dichloromethane) to give a solid which was triturated in methanol. The solid collected by filtration to give 2,5-bis-thieno[2,3-b]thiophen-2-yl- terephthalic acid diethyl ester (1 1 .68 g, 81 %) as a yellow solid. 1H-NMR (400 MHz, CDCIs) 1 .13 (6H, t, J 7.1 ), 4.24 (4H, q, J 7.1 ), 7.24 (2H, d, J 5.2), 7.26 (2H, s), 7.37 (2H, d, J 5.2), 7.88 (2H, s).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Diethyl 2,5-dibromoterephthalate.
Reference:
Patent; MERCK PATENT GMBH; MORSE, Graham; HEARD, Kane; MITCHELL, William; KROMPIEC, Michal; D’LAVARI, Mansoor; PRON, Agnieszka; (260 pag.)WO2019/52935; (2019); A1;,
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