Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 443-26-5, name is Ethyl 2-fluorobenzoate, A new synthetic method of this compound is introduced below., 443-26-5
A mixture of compound 20-1 (2 g, . 0535 mol), Boc piperazine 20-2 (3.32 g, . 017F mol, Aldrich), K2CO3 (7.39 g, . 0535 mol) and copper (. 0756 g, . 00119 mmol) in DMF (25 ML) was refluxed at 185 C overnight. The solution was cooled to room temperature, poured into 50 ML of ice water (50 ML) and extracted with EtOAc (3 x 50 mL). The combined organic layers were dried and concentrated in vacuo to give compound 20-3.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK & CO. INC.; WO2004/78716; (2004); A1;,
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