Related Products of 619-42-1, The chemical industry reduces the impact on the environment during synthesis 619-42-1, name is Methyl 4-bromobenzoate, I believe this compound will play a more active role in future production and life.
Eth nytfime hyisfiane (82.4 g, 0,84 mol) was added dropwise over 10 min under a nitrogen atmosphere to a solution of methyl 4-bromobenzoate (150 g, 0.7 mol), PdC (PPh3)2 (15 g, 0.021 mol) and Cu (13 g, 0.07 mol) in TEA (1.5 L) and the reaction was siirsd at 90 for 30 minutes. Solids were collected by filtration and washed with EtOAc (5 x 500 mL). The filtrate was concentrated under reduced pressure to give a residue, which was distilled under reduced pressure to yield methyl 4-C(trimethylsify) ethynyl) benzoate (INT-12) as an off-white solid (156 g, 96%),
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-bromobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ACHAOGEN, INC.; PATTERSON, Brian D.; LU, Qing; AGGEN, James Bradley; DOZZO, Paola; KASAR, Ramesh Annasaheb; LINSELL, Martin Sheringham; KANE, Timothy Robert; GLIEDT, Micah James; HILDEBRANDT, Darin James; MCENROE, Glenn A.; COHEN, Frederick; WO2013/170165; (2013); A1;,
Ester – Wikipedia,
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