Electric Literature of 5941-55-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5941-55-9, name is Ethyl (E)-3-Ethoxyacrylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of (E)-ethyl 3-ethoxyacrylate (12.6 g, 87.6 mmol) in 1,4-dioxane (50 mL) and water (50 mL) was added NBS (17.2 g, 96.4 mmol) at 0C. The mixture was stirred for 1 hour at room temperature. Benzothioamide (12.1 g, 87.6 mmol) was added and the mixture was stirred for 1 hour at 80-90C. The reaction mixture was cooled down to room temperature and poured into NH4OH (300 mL, 3% in water) and extracted with ethyl acetate (150 mL x 2), dried over sodium sulfate, concentrated and purified by chromatography (PE:EA =10/1) to give compound 10-la (2.9 g, 14% yield); LCMS (ESI): m/z 234 [M+Hf?.
The synthetic route of Ethyl (E)-3-Ethoxyacrylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TUFTS UNIVERSITY; HAYDON, Philip, G.; LEE, Jinbo; (160 pag.)WO2018/58148; (2018); A1;,
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