13831-03-3, Name is tert-Butyl propiolate, 13831-03-3, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
Step 3: 1 -[4-(tert-Butyl-dimethyl-silanyloxymethyl)-benzyl]-1 H-[1 ,2,3]triazole-4- carboxylic acid tert-butyl ester. Cupric sulfate pentahydrate (1 .03 g, 4.1 1 mmol) and sodium ascorbate (4.07 g, 20.6 mmol) are added to a stirred solution of (4-azidomethyl-benzyloxy)-tert-butyl-dimethy- silane (6.0 g, 20.6 mmol) and tert-butyl propiolate (3.10 ml, 22.6 mmol) dissolved in a mixture of 50 ml of tert-butanol and 50ml of water. The reaction mixture is stirred at room temperature for 2 hours. The solvent is removed under reduced pressure and the residue is partitioned between water and DCM. The organic layer is separated and concentrated under reduced pressure to obtain the crude title compound (Yield 8.3 g). LC (Method 4): tR = 0.73 min; Mass spectrum (ES+): m/z = 404 [M+H]+.
Statistics shows that tert-Butyl propiolate is playing an increasingly important role. we look forward to future research findings about 13831-03-3.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FRATTINI, Sara; BAKKER, Remko; GIOVANNINI, Riccardo; HAMPRECHT, Dieter; LINGARD, Iain; PAUTSCH, Alexander; WELLENZOHN, Bernd; (92 pag.)WO2017/72020; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics