10203-58-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10203-58-4, name is Diethyl isobutylmalonate, This compound has unique chemical properties. The synthetic route is as follows.
2-aminotetrahydropyrrolidine hydrochloride (1.33 g, 10 mmoL) was dissolved in 60 mL of anhydrous ethanol, and 1.33 mL of triethylamine was added dropwise with constant stirring, and the reaction was carried out for 10 min at room temperature.A solution of sodium ethoxide (1.36 g, 20 mmoL) in absolute ethanol (20 mL) was added dropwise on an ice bath and allowed to react for 45 min at room temperature after the addition was complete.A solution of diethyl isobutyl malonate (2.16 g, 10 mmoL) in absolute ethanol (20 mL) was added dropwise with constant stirring, and the temperature was raised and refluxed for 15 hours.After TLC tracking, after the reaction was completed, the mixture was filtered by suction and the filtrate was collected. The filtrate was evaporated and the solvent was removed to give a yellow solid.100 mL of water was dissolved and 100 mL of ethyl acetate was extracted three times. Fat-soluble impurities were removed and the aqueous phases were combined.Butanol was extracted and the n-butanol layer was collected, rotary evaporated and the solvent removed to give a pale yellow solid.The trichloromethane was dissolved, suction filtered to remove impurities that were insoluble in chloroform, and the filtrate was collected and spin-dryed to give a white solid as the compound 3-isobutyl-tetrahydropyrrole [1,2-a]pyrimidine-2, 4(1H,3H)-dione.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; Xi’an Jiaotong University; Guo Zengjun; Li Dandan; Zhang Jie; Zhang Hui; Liu Xia; Li Mengyi; Xi Ke; (13 pag.)CN104693205; (2017); B;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics