2555-28-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2555-28-4, name is 7-Methoxy-4-methylcoumarin belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: A general procedure for preparation of compounds 5, 9a-b and13: the corresponding N-bromosuccinimide (1.2 equiv) was addedslowly to a solution of 7-methoxycoumarin (1 equiv) and sodiumacetate (0.05 equiv) in DMF, and the mixture was stirred at 75 Cfor 6 h. After pouring into brine, and washing, then mixture wasextracted with ethyl acetate. The combined organic layers werewashed with brine, dried over anhydrous Na2SO4 and then filteredand concentrated in vacuum. The product was purified by columnchromatography (0-20% ethyl acetate in petroleum ether).
The synthetic route of 7-Methoxy-4-methylcoumarin has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yang, Lu; Hu, Zhiye; Luo, Junjie; Tang, Chu; Zhang, Silong; Ning, Wentao; Dong, Chune; Huang, Jian; Liu, Xianjun; Zhou, Hai-Bing; Bioorganic and Medicinal Chemistry; vol. 25; 13; (2017); p. 3531 – 3539;,
Ester – Wikipedia,
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