A common compound: 24398-88-7, name is Ethyl 3-bromobenzoate, belongs to esters-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 24398-88-7
The zinc reagent 2c was prepared according to TP1 from methyl3-bromo-4-(((trifluoromethyl)sulfonyl)oxy)benzoate (1c,7.26 g, 20 mmol), Zn-powder (3.92 g, 60 mmol) and InCl3(0.33 g, 1.5 mmol). The reaction mixture was stirred in DMPU(20 mL) at 50 C for 2 h. Iodolysis indicated a yield of 70% bimetallic reagent (14 mmol). The solution containing the zinc reagent was separated from the remaining zinc powder and transferred to a new flask containing a solution of ethyl 3-bromobenzoate (3e, 9.16 g, 40 mmol) and PEPPSI-iPr (0.19 g,0.28 mmol) in THF (20 mL). The reaction mixture was stirred at 50 C for 12 h before being quenched with HCl (2 M, 50 mL). Flash column chromatographical purification on silica gel(pentane/diethyl ether = 4:1) afforded 4e as a colorless oil (3.82 g, 8.83 mmol, 63%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 24398-88-7, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Klatt, Thomas; Bluemke, Tobias D.; Ganiek, Maximilian A.; Knochel, Paul; Synthesis; vol. 46; 3; (2014); p. 290 – 294;,
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